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Tuesday, November 3, 2020 | History

1 edition of Alendronate for the treatment of osteoporosis found in the catalog.

Alendronate for the treatment of osteoporosis

Alendronate for the treatment of osteoporosis

a symposium held in Amsterdam, the Netherlands, June 1995

by

  • 34 Want to read
  • 17 Currently reading

Published by Oxford University Press in Oxford .
Written in English

    Subjects:
  • Osteoporosis -- Treatment -- Congresses.,
  • Diphosphonates -- Therapeutic use -- Congresses.

  • Edition Notes

    Includes bibliographical references.

    Statementguest editor P.D. Delmas.
    SeriesBritish journal of rheumatology -- v. 316 suppl. 1 (June 1997), British journal of rheumatology -- v. 36, suppl. 1.
    ContributionsDelmas, P. D.
    The Physical Object
    Pagination26 p. :
    Number of Pages26
    ID Numbers
    Open LibraryOL22367014M


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Alendronate for the treatment of osteoporosis Download PDF EPUB FB2

Background: The Norwegian guidelines for prevention and treatment of osteoporosis and osteoporosis-related fractures recommend treatment with bisphosphonates for women with T-score less than and previous fractures and also for women with T-score less than or equal to without previous fracture. Only women with T-score equal to or less than who have previous fractures will Cited by: 2.

Thus, alendronate represents an important option for preventing and treating this common and debilitating disease. This article summarizes the wealth of data from FIT and other studies of alendronate in the context of the burden of illness associated with by: In this review, this new formulation of alendronate sodium hydrate (oral jelly) is introduced and discussed in terms of osteoporosis treatment.

This new formulation provides an alternative so that patients may select a method of dosing tailored to their preferences. Management of osteoporosis involves assessing fracture risk and preventing Cited by: Development of a Novel Transdermal Patch of Alendronate, a Nitrogen-Containing Bisphosphonate, for the Treatment of Osteoporosis Kosuke Kusamori, 1,*Hidemasa Katsumi, Mari Abe, 1Asuka Ueda, 1Ryota Sakai, Rie Hayashi, Yuka Hirai, 1Ying-shu Quan,1,2 Fumio Kamiyama,2 Toshiyasu Sakane, and Akira Yamamoto1 1Department of Biopharmaceutics, Kyoto Pharmaceutical University, Yamashina Cited by: Saag KG, Emkey R, Schnitzer TJ, et al.

Alendronate for the prevention and treatment of glucocorticoid-induced osteoporosis. N Engl J Med ; - Free Full TextCited by: Background: Osteoporosis is a common complication of long-term glucocorticoid therapy for which there is no well-proved preventive or restorative treatment.

Methods: We carried out two week, randomized, placebo-controlled studies of two doses of alendronate in men and women, 17 to 83 years of age, who were receiving glucocorticoid therapy.

Alendronate is one of the bisphosphonate drug treatments which are widely used to reduce the risk of broken bones in people with osteoporosis. Most people take it as a weekly tablet but it is also available as a weekly oral solution, effervescent tablet, or as a daily tablet. Why do I need a drug treatment for osteoporosis and how do the.

Objectives: To evaluate and compare the efficacy and safety of the combination of raloxifene and alendronate with those of monotherapies in elderly women with osteoporosis. Methods: Sixty-two postmenopausal women (mean age ± years) attending gynecologic osteoporosis clinics with established osteoporosis were randomly allocated to one of four treatment groups and monitored for.

Alendronate is approved for the prevention and treatment of osteoporosis in postmenopausal women and for the treatment of osteoporosis in men. It also is approved for the treatment of glucocorticoid-induced osteoporosis in men and women as a result of long-term use of steroid medicines (examples are prednisone and cortisone).

Alendronate reduces bone loss, increases bone Read more». Alendronic acid is a 'bisphosphonate' - a group of medications that work by slowing down the cells that break down bone. Bisphosphonates are the most commonly prescribed medication for people with osteoporosis and are often the first treatment option considered by your doctor.

Alendronic acid doesn't reduce the pain caused by broken bones. Treatment of Osteoporosis in Postmenopausal Women: Daily Dosing: The safety of alendronate in the treatment of postmenopausal osteoporosis was assessed in four clinical trials that enrolled women aged 44 to 84 years.

Study 1 and Study 2 were identically designed, three-year, placebo-controlled, double-blind, multicenter studies (United.

Alendronate helps to reduce the risk of fracture in people with osteoporosis and some other bone conditions. Dosage instructions, including remaining upright for at least 30 minutes and taking with a View more. Prolia is an injection that can be self-administered once every six months for the treatment of osteoporosis.

Uses: For the treatment of osteoporosis in postmenopausal women, men with osteoporosis, and men and women with glucocorticoid-induced osteoporosis receiving glucocorticoids in a daily dose equivalent to mg or greater of prednisone who have low bone mineral density.

Usual Adult Dose for Prevention of Osteoporosis. Background: Alendronate has been widely used in the treatment of osteoporosis. However, the effect of alendronate in the male osteoporosis remains controversial.

Study Question: We conducted a meta-analysis to assess the efficacy of alendronate in the treatment of men with osteoporosis. Study Design: PubMed, Embase, and Web of Science were searched from their inception to Octo Alendronate is FDA-approved for the treatment of postmenopausal osteoporosis, prevention of postmenopausal osteoporosis, steroid-induced osteoporosis, male osteoporosis, and Paget disease of the bone.

Alendronate is an option for maintaining or increasing bone-mass, although risedronate is the preferred agent in men with osteoporosis.[1]. Bisphosphonates are usually the first choice for osteoporosis treatment. These include: Alendronate (Fosamax), a weekly pill; Risedronate (Actonel), a weekly or monthly pill; Ibandronate (Boniva), a monthly pill or quarterly intravenous (IV) infusion; Zoledronic acid.

Fosamax (alendronate) is a bisphosphonate that treats osteoporosis and bone pain from metastatic breast cancer, multiple myeloma, and Paget’s disease. Common Fosamax (alendronate) side effects include stomach pain, nausea, vomiting, bloating, constipation, diarrhea, gas, black stool, change in taste perception, and muscle or joint pain.

Serious side effects of Fosamax include femoral. Introduction. Osteoporosis most commonly affects postmenopausal women, placing them at significant risk for sustaining fractures. Alendronate (ALN) is widely used as a first-line drug for the treatment of postmenopausal osteoporosis because of its established efficacy, according to the Fracture Intervention Trial and a recent systematic review of eleven randomized controlled trials (RCTs.

Among the nitrogen‐containing BPs, alendronate sodium (sodium‐4‐amino‐1‐hydroxybutylidene‐1,1‐bisphosphonate trihydrate) has been used as the first‐choice drug for the treatment of hypercalcemia and osteoporosis in postmenopausal women.

13 However, the oral bioavailability (BA) of alendronate is approximately % to %. 14 In. Hypocalcemia and vitamin D deficiency should be treated before beginning treatment with alendronate.

May cause mild transient increase of calcium and phosphate. Should be administered first thing in the morning with 6 to 8 ounces of plain water, 30 minutes before other medications, beverages, or food.

Objectives: Osteoporosis remains a clinical challenge. Teriparatide is an anabolic drug and alendronate is an antiresorptive agent; both are used in the treatment of osteoporosis.

Comprehensive reviews investigating the comparative safety and efficacy of teriparatide versus alendronate are scarce. Postmenopausal women with osteoporosis randomly assigned to either alendronate 70 mg OW or risedronate 35 mg OW for the month base study continued taking the same double-blind study medication.

Efficacy measurements were BMD at the hip trochanter, lumbar spine, total hip, and femoral neck and levels of four bone turnover markers at 24 months. To evaluate the efficacy of alendronate for the treatment of osteoporosis in thalassemia patients.

Methods In this randomized controlled trial, patients were included if there were males (18–50 years) or premenopausal females with low bone mineral density (BMD) (Z-score SD) or positive vertebral deformities from vertebral fracture.

The dual-action treatment; romosozumab leads to more pronounced increases in BMD than other treatment modalities and reduces the risk of vertebral and clinical fractures by 73% and 36% compared to placebo after 12 months and the sequential treatment regime; romosozumab for 12 months followed by alendronate reduced the risk of vertebral, non.

In a separate study, postmenopausal women with osteoporosis were randomized to receive either alendronate, teriparatide (at double the FDA‐approved dose), or both for 30 months (teriparatide was not started until month 6) and hip and spine BMD increased more in women treated with teriparatide alone than with combination therapy.

84 In a   In this study, alendronate treatment for 2 years improved and maintained skeletal bone mass. The optimal dosage, associated with minimal side effects, appears to be 5 to 10 mg. At such dosages, alendronate therapy appeared to be well tolerated and effective for the treatment of osteoporosis in postmenopausal women in this study.

The economic impact of alendronate treatment in men has not been analyzed yet. By assuming that the results in FIT are also applicable on men, this study aimed to estimate the cost effectiveness of alendronate in the treatment of male osteoporosis in Sweden.

The cost effectiveness will be analyzed both from a societal and a health care perspective. The World Health Organization (WHO) defines osteoporosis as a bone mineral density (BMD) of standard deviations below that of a young adults (T-score of − or lower).Severe osteoporosis is differentiated from osteoporosis by the presence of one or more fragility fractures in addition to BMD T-score below −The presence of fragility fractures has a clinically significant.

Osteoporosis is a common medical condition in older individuals, responsible for approximately million fragility fractures in the USA each year. Alendronate sodium with cholecalciferol (vitamin D3) is a newly developed combination formulation for the treatment of osteoporosis in women and for increasing bone mass in men with osteoporosis.

The treatment of osteoporosis with anti-resorptive agents is associated with an early decrease in markers of bone resorp-tionandalater decrease in markers ofbone formation. Inthe case of teriparatide (or PTH ), the principal index of response is an increase in indices of bone formation.

Several. User Reviews for Alendronate to treat Osteoporosis (Page 3) Also known as: Fosamax, Binosto. Alendronate has an average rating of out of 10 from a total of 62 ratings for the treatment of Osteoporosis.

11% of those users who reviewed Alendronate reported a positive effect, while 87% reported a negative effect. Overview; Side Effects; Dosage2/ Alendronate is a potent bisphosphonate that increases the bone mineral density of the hip, spine, and total b22 and lowers the incidence of vertebral, hip, and forearm fractures by.

alendronate had switched to generic alendronate by the end of the year (Yun et al. Alendronate was the first commercially-marketed amino-bisphosphonate for the treatment of osteoporosis and, consequently, the first to lose its patent and be provided to the market as a generic drug.

Recently, risedronate (5 mg/d and 35 mg/w doses) has. Alendronate for the prevention and treatment of men osteoporosis: a systematic review. Chinese Journal of Evidence-Based Medicine ; 6(3): A systematic review and economic evaluation of alendronate, etidronate, risedronate, raloxifene and teriparatide for the prevention and treatment of postmenopausal osteoporosis.

Etidronate and alendronate increase spinal BMD in postmenopausal women with osteoporosis. In one study, etidronate decreased the number of women sustaining new radiographic vertebral fractures over two years, but this effect was lost after three years of treatment.

Background Postmenopausal osteoporosis is a serious health problem, and additional treatments are needed. Methods We studied the effects of oral alendronate, an Cited by:   Effect of osteoporosis treatments on risk of non-vertebral fractures: review and meta-analysis of intention-to-treat studies Osteoporosis International Published online: 29 June Siris ES, Chen Y-T, Abbott,TA, et al.

Bone mineral density thresholds for pharmacological intervention to. Recent information about osteoporosis treatments and their nonfracture side effects suggests the need for a new costeffectiveness analysis. The authors estimate the cost effectiveness of screening women for osteoporosis at age 65 and treating those who screen positive with hormone replacement therapy (HRT), raloxifene, or alendronate.

The results presented here show that a drug treatment of arterial hypertension does not have any negative influence on the treatment of postmenopausal osteoporosis with alendronate. Clinical studies have demonstrated that there is a connection between cardiovascular diseases and an.

Treatment of osteoporosis with bisphosphonates. Endocrinol Metab Clin North Am. ;– Devogelaer JP. A risk-benefit assessment of alendronate in the treatment. We can conclude that alendronate is a well-tolerated, secure and efficacious treatment method for postmenopausal osteoporosis, male osteoporosis, and glucocorticoid induced osteoporosis (GIOP).

Methods. A total of postmenopausal women or men aged older than 50 years who met the indications for osteoporosis treatment were randomized to receive either generic (Bonmax ®) or brand alendronate (Fosamax ®) 70 mg/week over a month period during the May to June study nts included bone mineral density (BMD) changes at the lumbar spine, total hip.

Recommendations about which persons with osteoporosis should receive treatment vary.2, 6 The NOF recommends treatment of postmenopausal women and men with a personal history of hip or vertebral.